https://www.protondb.com/ is worth a look. It shows the state of games using Proton and people list their tweaks to make games work. You can filter it to only show Nvidia GPU’s on PopOS as an example too. To find tweaks more applicable to your system.

TS being worked on next http://www.openra.net/about/

Which distro are you using. Fedora, manjaro and few others disabled hardware acceleration for certain codecs making CPU and power spike. For Fedora you can enable RPM fusion and install the hardware acceleration versions and be back to normal .

https://rpmfusion.org/

I’ve been using this guide for ages.

https://fedoramagazine.org/automatically-decrypt-your-disk-using-tpm2/

A few sandwiches short of a picnic.