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Cake day: July 7th, 2023

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  • Well, when you reach out, are you in need of something? Sometimes it’s just and being like, “what up, fool,” or sending a meme that reminds of them or whatever. If you’re only ever reaching out because ultimately you want attention, time, etc, maybe that comes off as needy (though I think that’s ok too!), but sometimes reaching out is just, like, “hey, thought of you, I don’t need anything!”


  • I’m in my late 30s, and I have found that making friends is different, but not necessarily harder. If you’re still thinking back to high school/college days where you had “the boys” or “the girls,” that’s just not realistic. People have jobs, hopefully careers, spouses, kids. If your primary focus is on exclusive friend time in your 30s, that is very difficult to find. Most people have more than just friends going on in their lives–unlike in high school and college, where people typically had friends going on and lives that wrapped around it.

    I’m fairly affable and outgoing, which helps, but I enjoy making friends with people that aren’t. It’s easier, and the best friends I’ve made over the last few years are people that aren’t very outgoing, but they like being around and hanging out with an outgoing person. But that does mean that I’m usually the one to strike up conversation, ask for a number, drag them out when I’ve got free time, etc. To be honest, many of these friends don’t necessarily make it easy to socialize with them, because it takes them out of their comfort zone. I’m aware of that, so I don’t mind the extra prodding and encouragement that it takes, but I think if you’re more like that, the best thing you can do is just try to decrease the amount of drag you add to trying to be friends (even though you might be unaware that you’re adding that “drag”). Often people will just be like “ok. They don’t want to hang,” and they’ll move on. I just grew up with friends that were always kind of like that, so I just know they tend to need a little more love and encouragement.

    Beyond that, just prioritize friendship maintenance. Text people periodically, see how they’re doing, etc. Friends are like plants: when they’re new, they require a lot of watering and maintenance, once they’re established, they require less. But you can’t expect a new plant to take well to the treatment of an established plant with deep roots. You’ve gotta nurture it.


  • So it generated known chemical weapons as well as previously unknown compositions that to all appearances would be effective chemical weapons. They didn’t actually test them for obvious reasons, but their animal toxicology models made pretty clear they would be effective toxic chemical compositions that could easily be weaponized and it did it in six hours.


  • So it generated known chemical weapons as well as previously unknown compositions that to all appearances would be effective chemical weapons. They didn’t actually test them for obvious reasons, but their animal toxicology models made pretty clear they would be effective toxic chemical compositions that could easily be weaponized and it did it in six hours.


  • An article on the subject.

    FTA: "In responding to the invitation, Sean Ekins, Collaborations’ chief executive, began to brainstorm with Fabio Urbina, a senior scientist at the company. It did not take long for them to come up with an idea: What if, instead of using animal toxicology data to avoid dangerous side effects for a drug, Collaborations put its AI-based MegaSyn software to work generating a compendium of toxic molecules that were similar to VX, a notorious nerve agent?

    The team ran MegaSyn overnight and came up with 40,000 substances, including not only VX but other known chemical weapons, as well as many completely new potentially toxic substances. All it took was a bit of programming, open-source data, a 2015 Mac computer and less than six hours of machine time. “It just felt a little surreal,” Urbina says, remarking on how the software’s output was similar to the company’s commercial drug-development process. “It wasn’t any different from something we had done before—use these generative models to generate hopeful new drugs.”"